Running samples through armies of electron microscopes is too expensive and too slow.
100 Billion CPH, which literally means 100 billion cells per hour, is a project investigating highly parallel neuroimaging technologies that could make that kind of throughput possible, potentially at far lower cost than the trillions of dollars that could be required to reproduce a single full human connectome over decades using EM or ExM methods.
Our platform of choice is nano and microrobots(depicted below) interfacing with individual neurons/glial cells and recording up to sub-cellular informatics in real time while minimally disrupting the cell's dynamics. The nanoprobes would be equipped with chemosensors, onboard information-processing systems inspired by work such as Miskin et al., and nanowire-based information-routing systems to move information to external computers.
These cell-state recordings would be taken gradually by a (currently hypothetical) mesh network of permanently-implanted nano robots in the body and especially densely in the brain.
100 Billion CPH is funded by Nanocytronic Inc and plans to start experimental work as soon as Mid-2027.